Republic of Ireland vs Armenia (Group B)
With Russia needing a point from their final game at home to Andorra to guarantee topping Group B, the main battle is for second position and a play-off place.
Republic of Ireland boast a one-point advantage over surprise package Armenia, with the two sides due to meet in Dublin tonight.
Ireland are expected to claim the point they need, but are likely to be without record goalscorer Robbie Keane, who suffered a muscular injury on Friday. Richard Dunne is available again, though, after being suspended for last week's game.
Armenia have won their last three matches, scoring 11 goals in the process, and are already guaranteed their best ever qualifying campaign despite fielding one of the youngest sides in the competition.
"Armenia is a very, very strong team," said Ireland boss Giovanni Trapattoni. "They have scored more goals than us and we must pay very much attention."
France vs Bosnia and Herzegovina (Group D)
The stage is set for a winner-takes-all encounter at the Stade de France, with group leaders France holding a one-point advantage over second-placed Bosnia after both sides won on Friday.
Under the calming leadership of Laurent Blanc, the French have made a decent fist of bouncing back from last summer's calamitous World Cup.
Blanc has successfully blended some emerging talent with a core of players who under-performed so spectacularly in South Africa, and will be confident of his side claiming they point they need to qualify this evening despite the absence of Karim Benzema, Franck Ribery, Bacary Sagna and Eric Abidal.
Bosnia have already exceeded expectations and, after a run of four consecutive victories guaranteed a play-off place, are approaching tonight's decider with nothing to lose.
"We will travel to Paris in a relieved frame of mind because we have already achieved our initial goal," said captain Emir Spahic, who plays his club football with Sevilla. "France are a top team and even if they are missing some players they will be strong. But we could beat them."
Denmark vs Portugal (Group H)
With Portugal and Denmark level on points at the top of Group H, tonight's meeting of the two teams in Copenhagen could hardly be more pivotal.
Portugal go into the game with a slight advantage as October's 3-1 home win over Denmark means a draw tonight would see them top Group H courtesy of a better head-to-head record.
Paulo Bento's Portugal side have improved as the qualifying tournament has gone on, and have scored nine goals in their last two matches with Manchester United winger Nani particularly prominent.
Denmark have been in fine form themselves, though, scoring four goals in 22 minutes on Friday evening to rout Cyprus.
The losers tonight are guaranteed a play-off place, but there could yet be an even better silver lining as either side could edge out Sweden to claim the one automatic qualifying spot available to the best runners-up from all nine groups.
Spain vs Scotland (Group I)
Unsurprisingly, Spain have already qualified for Euro 2012 with a perfect record, but tonight's final fixture could hardly be more important to their opponents, Scotland.
The Scots hold second position in Group I, so a win, however unlikely it would seem, would guarantee a play-off place.
Assuming Craig Levein's side do not pull off one of the biggest surprises in their history, though, Scotland must match whatever the Czech Republic achieve in their final fixture.
The Czechs travel to Lithuania having lost to Spain themselves on Friday, so events in Kaunas will be closely monitored as Scotland attempt to achieve the seemingly unachievable in Alicante.
"It is a tall order, but it is a one-off match," said Levein. "You saw the first time around at Hampden (when Spain beat Scotland 3-2) that we are capable of scoring goals and the boys have won six of their last nine matches, so we're going into this game in good spirits."
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