ALEXANDER ISAK will not be involved in Newcastle United’s midweek Carabao Cup game with AFC Wimbledon, and is already an early doubt for next weekend’s Premier League meeting with Everton.

Isak was not involved in today’s 1-1 draw with Manchester City as he is struggling with the broken toe he sustained in the recent win over Wolves.

While Isak played at Fulham last weekend after having a painkilling injection prior to kick-off, he was not risked against the reigning champions this afternoon.

He will not be involved in Tuesday’s League Cup third-round tie, with his participation in next weekend’s trip to Goodison Park hanging in the balance.

“He (Isak) definitely won't feature on Tuesday,” said Howe. “Let's see how he looks for Everton, and of course there's an international period coming up after that and he's an international player, so we'll see the implications of all that.

“But we'll make decisions during this week. We know it's not a serious injury, but it's a niggly one that's obviously preventing a key player playing for us.”

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Newcastle’s medical staff will also spend the next couple of days monitoring the wellbeing of Sandro Tonali and Kieran Trippier, who were both forced off in the second half of today’s game.

Tonali was suffering from cramp as he left the field, and Howe is hoping Trippier’s leg problem was also cramp-related rather than anything more serious.

The Magpies boss was delighted with the way the duo gave their all during their time on the pitch, although it seems unlikely that will either be starting against Wimbledon in the week.

“I think that’s how you want a player to exit the pitch,” said Howe. “That’s the difference between this week and last week (against Fulham) – both players had given everything they could, they couldn’t have given any more and they had to come off.

“I always say to the players, ‘That’s how I want you to play’. For different reasons, both of those players had had broken pre-seasons.

“You can still see Sandro has a little bit of fitness work to do to get back to his best, and he comes off with cramp. We’re hoping Kieran is just cramp too, although we’re not 100 per cent sure at this moment. It was a really good display from both players.”