Crook Town bid to win their first league game of the season at home to Jarrow Roofing today.
Crook are bottom of the table but were given a much-needed boost when they won at Peterlee in the League Cup in midweek.
They will give debuts to keeper Jason Scotter and defender Neil Moan, while midfielder Darren Hickey will have a fitness test.
Some of the credit for their midweek revival is down to assistant manager Mark Linighan in the centre of defence, and skipper Andrew Strong.
Roofing have several injury doubts following their midweek cup defeat at Shildon and keeper Micky Norris will be out for the season with a broken leg.
Billingham Synthonia, who have lost only once in the league, can climb into the top six if they beat Morpeth at Central Avenue.
Striker Kraig Wilkinson and defender Kenny Davies are both ruled out, while full back Dean McGee and defender Tommy Marron will have late fitness tests.
Guisborough, who are at Consett, include new signing Steve Makin from Spennymoor in their squad, but they will be without midfielder Stephen Bell and strikers Chris Fuller and Darren Ward.
Consett are still without striker Colin McLeod and midfielder David Gray, but Rod Butler returns.
Dunston can move closer to leaders Bedlington by defeating Hebburn at Federation Park. Full back Micky Farrey is expected to return after injury while Gary Forbes comes back into the midfield.
Peterlee manager Eddie Freeman is hoping his side will take their chances away to Brandon after their disappointing defeat by Crook. However, his priority is to find a keeper, as regular Simon Corbett is injured and stand in Paul Pringle is unavailable. Jon Keegans, Robbie Ferguson and Alan Martin are all out.
Brandon welcome back three players who missed the midweek defeat at Guisborough, and they could give a debut to midfielder Paul Terrell from Washington.
In the second division, Shildon will include 17-year-old keeper Drew Inglis against Kennek Ryhope, but they will be missing Dale White, Darren Watkins and Terry Stones.
Northallerton, who are at Prudhoe, will be missing striker Andy McCreesh.
Willington, who face Penrith, are without three defenders for various reasons, while they have added new keeper James Farley to the squad.
Thornaby have three players missing for their trip to Ashington.
Chester-le-Street, who take on Newcastle Blue Star in the League Cup, are without Peter Symm
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