MP Gerry Steinberg is opposing the latest plan to turn a disused cinema into a nightspot.
He has lodged an objection to Worcestershire firm Tribecka Estates' planning application for the Palladium, in Claypath, Durham City.
The company hopes Durham City Council will give it permission to use the building, which has stood empty for years, as a restaurant and bar, with dancing and entertainment.
Mr Steinberg fears it will mean more problems for residents in the area, who already have to endure noise and drunken trouble at night.
He said: "The proposal is scarcely, if at all, different to previous planning applications at this location, which have been rejected as inappropriate.
"The last thing the city needs is a nightclub on Claypath, open until the early hours of the morning.''
Mr Steinberg said Claypath already had a number of pubs and restaurants, as well as houses and flats.
He said "The proposal would mean a further influx of revellers and extended opening hours, prolonging the period during which city residents have to endure the consequence of such activities."
J D Wetherspoon, the national real ale chain, whose pubs have no music, fruit machines or TV screens, was refused planning permission for the Palladium last year.
City council planning officials had said the firm's pub plan would have a big impact on the lives of elderly residents in the nearby Claypath Court flats.
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