Billingham Town were rubbing their hands with glee after their 7-0 win over Fleetwood Freeport earned them £7,500 on Saturday.
The FA have substantially increased the competition prize money this season, and Town manager Alan Robinson said that it would make a "huge difference" to the club.
"The FA Cup has certainly got an edge to it, now that there is a lot of prize money on offer," he said.
"It is a lifeline to us, and our chairman is delighted because it will keep the club going into the New Year."
There could be more to come, as there is another £7,500 on offer in the next round.
Town ran riot against the North West Counties League side.
Steve Osbourne set up Paul Rowntree to open the scoring early in the game, then Robbie Hutchinson provided the pass for him to score the second.
Osbourne gave them a grip on the game when he headed a third just after half time, then Stuart Jackson, Osbourne and two identical goals from Mark Casey put Town into the next round, where they will play Spennymoor.
Moors defeated Cheadle 2-0, but they needed two second half goals from a Chris Leonard header on 49 minutes and Tony Skedd 15 minutes from time.
Durham City had a good 3-0 away win at Louth United, to give them a home tie against UniBond title contenders Lancaster City.
They took the lead when Lee Ludlow cut in from the right and shot across the keeper, then Glen Moan added the second with a header from ten yards.
Recent signing David McMahon sent Ludlow through, and the striker rounded the keeper for the third.
Whitley Bay defeated UniBond League side Workington 1-0 at Hillheads.
Kevin Walton scored with a powerful shot from twenty yards just five minutes from the end.
Dunston are through after beating Hallam 3-1.
They got off to a great start when new signing Steve Mason scored from an Andy Elliott pass, then Mason turned provider after 43 minutes, giving Andy Fletcher the chance to fire home.
Hallam battled back in the second half and pulled a goal back, but Mason popped up with the third just five minutes from the end.
Bedlington are also in the next round after beating fellow Northern League side Peterlee 2-0.
However, they had to wait until the last fifteen minutes before clinching victory.
Dean Gibb scored from a pass by Tony Chapman after 76 minutes, then Steve Boon fired a second in the last minute.
Crook Town still have a chance of going through after they were held to a 1-1 draw by Pickering.
Stefan Zoll put Pickering ahead, but youngster Steven Roberts equalised with ten minutes to go.
But several ANL clubs went out.
Billingham Synthonia surprisingly lost 2-0 at home to Liversedge, while Brandon had a bad day against Kendal, losing 3-1, their goal only a late consolation from Richie Pitt
Easington narrowly lost 3-2 at Stocksbridge, nearly snatching a draw after Ian Matthews and Lee Dixon pulled them back into the game.
Guisborough lost by the same scoreline at Rossendale. Jamie Clark put them into an early lead, but the UniBond side came back to lead 3-1.
Clark pulled a late goal back, and Darren Mowbray was denied right at the death.
Horden, who had a good run last season, went out 2-1 at home to Witton Albion, Darren Atkinson scoring in the second half.
Shildon suffered their first defeat of the season when they were thrashed 8-2 at home by Brigg Town. Ashington lost 6-1 to Ramsbottom United, after going two goals down in the opening 15 minutes.
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