The A64 is set to be closed over some weekends and also have temporary traffic lights put in place as part of works.
National Highways will be carrying out work to replace drainage gullies and resurface the carriageway between East Knapton and West Heslerton, from Monday September 26.
Gully work on the major road is set to take place overnight between 8pm and 6am on Mondays to Thursdays and between 9pm and 6am on Fridays.
Traffic is set to be controlled by temporary traffic lights, allowing the road to remain open for some time.
Resurfacing works will also take place meaning the road will have to be closed in both directions over two to three full weekends.
Full closures will be in place from 8pm on Fridays to 6am on Mondays on weekends of November 4 and 7, November 11 to 14 and, if required, November 18 to 21.
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National Highways say the work is to smoother journeys for road users.
Chris Dunn, project manager at National Highways, added: “We’ll carry out these improvements in two phases.
“We will replace drainage gullies with new and improved lids along the edge of the carriageway to reduce wear and tear around the edges and with it the need for ongoing repairs in the future.
“This phase should be complete by Wednesday, 2 November which will allow us to start the second phase, the resurfacing.
“During closures, a fully signed diversion will be in place. This has been agreed in advance with police and the local authority.
“Eastbound traffic will be diverted onto the A169 at Malton, the A170 at Pickering and the B1261 to Staxton until re-joining the A64; the diversion for the westbound closure is the same route in reverse. “
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